KMID : 1188320090030010026
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Gut and Liver 2009 Volume.3 No. 1 p.26 ~ p.30
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Plasma 5-Hydroxytryptamine Concentration and Its Correlation with Psychopathology in Patients with Irritable Bowel Syndrome
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Park Seon-Young
Park Min-Ho Yoon Kyoung-Won Cho Sung-Bum Lee Wan-Sik Park Chang-Hwan Kim Hyun-Soo Choi Sung-Kyu Rew Jong-Sun
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Abstract
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Background/Aims: Irritable bowel syndrome (IBS) is a biopsychosocial disorder. 5-Hydroxytryptamine (5-HT)
plays a crucial role in the control of gastrointestinal motility, sensation, and secretion. This study investigated changes in platelet-depleted plasma 5-HT and their correlation with psychopathology in IBS patients and healthy subjects.
Methods: This study involved 21 subjects with IBS and 13 healthy subjects. Fasting and 1-hr postprandial plasma 5-HT concentrations were measured. The SCL-90R symptom checklist was used for the assessment of current psychological symptoms.
Results: Fasting and postprandial plasma 5-HT concentrations were significantly higher in IBS
patients (15.11¡¾13.51 ng/mL and 16.31¡¾14.21 ng/mL, respectively) than in healthy subjects (5.55¡¾4.14 ng/mL and 6.25¡¾4.82 ng/mL, respectively; p£¼0.05). There were no significant changes between fasting and 1-hr postprandial 5-HT concentration in IBS subtypes and healthy subjects. Scores on all SCL-90R subscales except for the interpersonal-sensitivity subscale were significantly higher in IBS patients than in healthy subjects. No correlation was found between
SCL-90R items and platelet-depleted plasma 5-HT concentration.
Conclusions: 5-HT might play a critical role in IBS, and psychopathological factors are correlated with IBS.
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KEYWORD
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Irritable bowel syndrome, 5-hydroxytryptamine, Psychopathology
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